A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides*

A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides*

The T cell receptor (TCR) orchestrates immune responses by binding to foreign peptides presented at the cell surface in the context of major histocompatibility complex (MHC) molecules. Effective immunity requires that all possible foreign peptide-MHC molecules are recognized or risks leaving holes in immune coverage that pathogens could quickly evolve to exploit. It is unclear how a limited poo...

How a Single T Cell Receptor Recognizes Both Self and Foreign MHC

alphabeta T cell receptors (TCRs) can crossreact with both self- and foreign- major histocompatibility complex (MHC) proteins in an enigmatic phenomenon termed alloreactivity. Here we present the 2.35 A structure of the 2C TCR complexed with its foreign ligand H-2L(d)-QL9. Surprisingly, we find that this TCR utilizes a different strategy to engage the foreign pMHC in comparison to the manner in...

A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity

The 2C T cell is a CD8+, alloreactive T cell, which recognizes cells bearing Ld and Kbm3 class I major histocompatability complex molecules. Here, we characterize an allopeptide, designated dEV-8, that is a ligand in the Kbm3 molecule for the 2C TCR but is not a ligand in the Ld molecule. By biochemical and immunological properties, dEV-8 is distinct from P2Ca, the Ld allopeptide that is also r...

A Movie Is Worth More Than a Million Data Points

This paper describes a distributed visualization system called Spiegel, which displays and analyzes the results of N -body simulations. The result of a N -body simulation is an enormous amount of data consisting of information about how the bodies interact with each other over time. The analysis of this data is difficult because it is not always clear ahead of time what is important. The visual...

Thy - 1 : More than a Mouse Pan - T Cell